EGFR and cancer: Radiomics is generally considered a good solution to these issues: First, radiomics can help guide patients on the need for further genetic sequencing, as it can derive information from all parts of the tumor images 19; Second, the correlation between radiomics and genomics can guide biopsy site selection to address the high error rate of histopathology due to sampling errors 20,21; Third, radiomics can accurately predict valuable biomarkers in cancers, such as IDH mutations in glioma 22-24, and EGFR amplification in lung cancer 25.