HMGB1 and neoplasm: Moreover, Hubert et al. have observed that HMGB1 inhibition remodels the breast cancer microenvironment, which involves a dramatic reduction in monocyte/granulocyte myeloid-derived suppressor cells and regulatory T lymphocytes, an elevated M1/M2 ratio of tumor-associated macrophages, and an enhancement of DCs and plasmacytoid DCs activation 104.