TBK1 and cancer: In addition to promoting inflammatory gene transcription, TBK1 plays vital roles in other signaling pathways, including the protein kinase B (AKT/PKB) survival signaling, mechanistic target of rapamycin kinase (mTOR), and epidermal growth factor receptor (EGFR) pathways, which are also closely regulated by TBK1 to support cancer development 6-14.