ATP7B and Wilson disease: Specifically, the tests should first inquire about the possible presence of rs367956522 and Gly869Arg (rs191312027), and if they are not present in their homozygous or compound heterozygous forms, then try Gly1405Ser (rs189601972), Met33Thr (rs184868522), and the six polymorphisms located in the UTRs that have not been reported or that have been interpreted as of uncertain significance. ATP7B exome sequencing should be undertaken only after all these polymorphisms are shown not to be in their homozygous or compound heterozygous forms in a WD case.