Our studies are also supported by the studies finding that hyperglycemia can also cause changes in hemodynamics, produce chronic stress on vascular endothelial cells, and destroy the original structure and function of microvessels, causing myocardial ischemia [24], suggesting that patients with diabetes may increase the risk of coronary vascular bypass grafting, possibly due to insulin resistance and activation of inflammatory responses in diabetic patients [26]. This evidence concerns the gene INS and diabetes mellitus.