Inhibition of FXa/FIIa can downregulate the activation of the Smad2/3 signaling pathway and MMP2 expression mediated by protease-activated receptor 2 (PAR2) to limit the severity of aortic aneurysm and atherosclerosis (Moran et al., 2017). Here, F2RL1 is linked to aortic aneurysm.