The homeobox protein Hox-C8 (Hoxc8), a sequence-specific TF that is part of a developmental regulatory system that provides cells with specific positional identities along the anteroposterior axis and is related to proinflammatory and immunological genes and pathways in coronary artery disease (Tan et al., 2020). This evidence concerns the gene POU2F2 and coronary artery disorder.