Except for these genes, CASP8, GBP5 and LUCAT1 have been reported to play multiple roles in numerous cancer types, such as head and neck cancer, oral squamous cell carcinoma, esophageal squamous cell carcinoma, colorectal cancer and HCC.46, 47, 48, 49, 50, 51, 52, 53. This evidence concerns the gene CASP8 and oral cavity squamous cell carcinoma.