Among the 10 genes that constructed the risk score, 7 genes (F2RL2, SLC35G2, C11orf53, AC008271.1, RP11‐114B7.6, RP11‐149I23.3 and RP11‐383 J24.1) have never been studied to be associated with HCC. The gene discussed is F2RL2; the disease is hepatocellular carcinoma.