Except for these genes, CASP8, GBP5 and LUCAT1 have been reported to play multiple roles in numerous cancer types, such as head and neck cancer, oral squamous cell carcinoma, esophageal squamous cell carcinoma, colorectal cancer and HCC.46, 47, 48, 49, 50, 51, 52, 53. Here, CASP8 is linked to esophageal squamous cell carcinoma.