Significant focal copy number changes as identified by GISTIC analysis (q-value of < 0.001) occurred on chromosomes 3, 9, 16 and 22 in regions that contain tumour suppressor genes, BAP1 (chr3), CDKN2A (chr9) and NF2 (chr22) (Fig. 1F). The gene discussed is BAP1; the disease is neoplasm.