TGFB1 and cancer: CCL2 is involved in the polarization of monocytes into M2 macrophages in the TME of a variety of cancers [79] including MPM [80], in agreement with this we detected high expression of CCL2. Similarly, we confirmed high TGFB1 expression, which is also involved in M2-like macrophage polarization [81], and an association with a poorer outcome [82].