PBRM1 and neoplasm: Genomic near-haploidization, that is a genome wide LOH, has been previously described for five MPM tumours [4] which were all BAP1, PBRM1 and SETD2 wildtype, with all of the cases containing inactivating point mutations in, or homozygous deletion of, SETDB1. In agreement with this, the sample with genome wide LOH in our cohort was also BAP1, PBRM1 and SETD2 wildtype with a SETDB1 inactivating mutation (frameshift deletion, chr1:150923937 AGAAG>-).