However, repression of TGF-β1 maybe not be a promising therapeutic option for OA when considering the crucial roles of TGF-β1 in cartilage homeostasis and repair [14, 15]. Additionally, increasing studies indicated TGF-β1 was also a chondroprotective factor in cartilage maintenance and TGF-β1 released by mesenchymal stromal cells attenuated the development of osteoarthritis [16, 17]. This evidence concerns the gene TGFB1 and osteoarthritis.