For instance, VMK1 was the first mitogen-activated protein kinase (MAPK) characterized as a positive regulator of MS development and pathogenicity [55]; VdHog1, a homolog of the yeast high-osmolarity glycerol (HOG) response kinase, is responsible for the development of melanized MS that are resistant to osmotic stress [56]. Here, WNK2 is linked to myeloid sarcoma.