UBE3A and cancer: The next important step for AS research, almost 30 years after the first description of AS by Harry Angelman, was actually made in the cancer research field, when Huibregtse and colleagues identified an E3 ubiquitin ligase associated with the human papilloma virus E6 protein (E6-associated protein or E6-AP), which was later named ubiquitin E3 ligase A (UBE3A) (Huibregtse et al. 1993).