PCDH15 and central nervous system cancer: As the Akt signalling pathway regulates actin polymerisation in human glioblastoma multiforme cells and human glioma-initiating cells47 and the Akt/mTOR (mechanistic target of rapamycin) pathway is a critical regulator of OPC differentiation, including actin polymerisation and depolymerisation37,48, we explored the possibility that Pcdh15 influenced F-actin levels in OPC lamellipodia by regulating Akt expression or activity.