Consequently, transcription of miR-142 is epigenetically inhibited, and miR-142-3p/5p expression in CD4+ T cells in SLE is reduced, which upregulates the expression of CD40L, ICOS and CD84, increases the production of IL-10 and IL-21, and promotes IgG production by B cells. This evidence concerns the gene CD40LG and systemic lupus erythematosus.