Another study by our team proved that UHRF1 downregulation leads to decreased DNA methylation and H3K27me3 levels in the BCL-6 gene promoter region, promoting Tfh cell differentiation in SLE; this effect is probably a result of the interaction of UHRF1 with DNMT1 and EZH2, which forms a regulatory complex of gene promoters [11]. This evidence concerns the gene UHRF1 and systemic lupus erythematosus.