CLN3 and juvenile neuronal ceroid lipofuscinosis: Comparing the effects of acidified drinking water on brain pathology in Cln1R151X mice with that in Cln3−/− mice (a model of juvenile CLN3 Batten disease) in our previous study1, there were only two common changes: reduced astrocytosis in the S1BF cortex and decreased microglial activation in the thalamus.