KLK3 and prostate cancer: A good estimate for PSA screening is that it leads to five additional cases per every prostate cancer death prevented10; a paper on a PRS reported that the proportion of cancers in the top 10%, 33%, and 50% of PRS risk approached 33%, 60%, and 80% respectively11; a different PRS was found to have almost identical hazard ratios irrespective of whether the endpoint was prostate cancer, aggressive prostate cancer, or prostate cancer death12.