A good estimate for PSA screening is that it leads to five additional cases per every prostate cancer death prevented10; a paper on a PRS reported that the proportion of cancers in the top 10%, 33%, and 50% of PRS risk approached 33%, 60%, and 80% respectively11; a different PRS was found to have almost identical hazard ratios irrespective of whether the endpoint was prostate cancer, aggressive prostate cancer, or prostate cancer death12. Here, KLK3 is linked to Familial prostate cancer.