TP53 and Miyoshi myopathy: In a multivariate analysis including chromothripsis and classical MM risk factors, such as bialleleic TP53 inactivation, t(4;14), amp(1q) and ISS we show that the presence of chromothripsis retains its independent impact on prognosis alongside amp(1q), biallelic TP53 inactivation, and ISS3 for OS and amp(1q) and ISS3 for PFS, Fig. 4.