UGCG and liver cancer: To confirm that GBA1 inhibition-promoting metastasis of liver cancer is mediated by GlcCer, we treated cells with PDMP, an inhibitor of GCS that synthesises GlcCer from Cer (Fig. 6A), to observe the effect of GlcCer changes on the inhibitory effect on the migration and invasion of HepG2 cells with GBA1 knockdown.