Next, we analysed the expression of GBA1 in several liver cancer cell lines with differing metastatic potential, and the results showed that the expression of GBA1 was profoundly decreased in MHCC-97H, MHCC-97L and SK-Hep1 with high metastatic potential compared with that in HepG2 and Huh7 with lower metastatic potential (Fig. 1J, K). The gene discussed is GBA1; the disease is liver cancer.