Notably, with the combination of anti-inflammatory and antioxidant effects, the expression of Nrf2 downstream ARE-dependent genes in RAW264.7 and BMDMs, including HO-1, Prdx1, NQO1, and GCLM, were distinctly upregulated in 4-OI treated group (Figs. 5b, S11). The gene discussed is NQO1; the disease is osteogenesis imperfecta.