Analogous gene expression profiling in immune cells isolated from patients with acute myeloid leukemia (AML) identifies co-expression of both POLR3G and POLR3GL mRNA in pre-leukemic hematopoietic stem cells (pHSCs), leukemia stem cells (LSC), and leukemic blast cells (Blast) (Supplementary Fig. 3a). The gene discussed is POLR3G; the disease is leukemia.