TMPRSS2 and metabolic syndrome: Males compared with females (OR = 0.586), a higher CCI (OR = 1.126) (covariates), dyslipidemia (OR = 2.289), and TMPRSS2 rs75603675 (C/C or C/A diplotypes, compared with the A/A diplotype) (OR =2.140) were significantly related to a higher severity 1 and 2 status, after multivariate analysis and Bonferroni correction for multiple comparisons (Fig 1).