Several genes encoding lipid metabolic regulators have been identified as NAFLD risk loci; the most reproducible being patatin-like phospholipase domain containing 3 (PNPLA3) and transmembrane 6 superfamily member 2 (TM6SF2) (5, 6, 7, 8). The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.