Since the original GWAS study by Buch et al. in December 2015 linking the rs641738 SNP near MBOAT7 to liver disease, there has been tremendous progress in our understanding of how MBOAT7 is mechanistically linked to the progression of ALD-, NAFLD-, and viral-driven cirrhosis and HCC. The gene discussed is MBOAT7; the disease is metabolic dysfunction-associated steatotic liver disease.