This initial cis expression quantitative trait locus was an extremely important observation given that the rs641738 locus is actually positioned in exon 1 of the TMC4 beyond the 3′ untranslated region of MBOAT7 (Fig. 1) and provided early evidence that the causal gene in the locus is MBOAT7 and not TMC4. This seminal study by Buch et al. set the stage for other validation studies in ALD as well as other liver disease etiologies. This evidence concerns the gene MBOAT7 and liver disorder.