Collectively, the work by Meroni et al. (38) bolsters the idea that MBOAT7 expression is downregulated in mouse models of obesity (ob/ob) or NAFLD/NASH progression (methionine choline-deficient diet) and confirms that Mboat7 knockdown in mice promotes hepatic steatosis. This evidence concerns the gene MBOAT7 and obesity due to melanocortin 4 receptor deficiency.