This article also demonstrated that hepatic expression of MBOAT7 is reduced in obese humans and rodents, independent of rs641738 status, and that the expression of Mboat7 in the liver and adipose tissue of mouse is negatively correlated with obesity and insulin sensitivity across all the strains represented by the Hybrid Mouse Diversity Panel (37). Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.