In a simple yet elegant follow-up study, Xia et al. (41) then crossed Mboat7HKO mice to mice lacking SREBP cleavage-activating protein (Scap) and found that the hepatic steatosis observed in Mboat7HKO mice is not evident in Mboat7HKO mice that fail to activate the SREBP transcription factors (i.e., Mboat7HKO mice + Scap−/−). Here, SCAP is linked to fatty liver disease.