1st biopsy - showed mild mesangial proliferation with granular diffuse IgA and C3 deposits and some scanty intratubular crystals assumed as, 2nd biopsy - persistence of mild IgA nephropathy, interstitial inflammation, and diffuse deposits of intratubular brown crystal, 3rd biopsy - showed persistence of intratubular brown crystals with interstitial inflammatory infiltration and fibrosis uric acid. The gene discussed is C3; the disease is inflammatory response.