Intriguingly, we found two members of the very small group of metabolic enzymes that are altered in cancers in the list of potential p53 interactors in growth medium: D-3-phosphoglycerate dehydrogenase (PHGDH) [42, 43] and Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1), the latter of which is involved in the regulation of the oncometabolite d-2-hydroxylglutarate [44]. This evidence concerns the gene PHGDH and cancer.