Weight loss can not only improve hypertension, dyslipidemia, and insulin resistance, but can also lead to reductions in inflammatory biomarker concentrations [25–28] (CRP, TNF-a, IL-6, IL-8, etc.), and an increase in the expression of the anti-inflammatory markers adipokines [29, 30], especially in those investigations assessing a weight loss of at least 10%. The gene discussed is TNF; the disease is metabolic syndrome.