ACEi, angiotensin converting enzyme inhibitor; LA:Ao, left atrial to aortic root ratio; E wave velocity, peak transmitral flow in early diastole; LVIDDN, left ventricular internal diameter in diastole normalised to bodyweight (kg0.294); LVIDSN, left ventricular internal diameter in systole normalised to bodyweight (kg0.315); TR, tricuspid regurgitation. This evidence concerns the gene ACE and tricuspid valve insufficiency.