Additionally, CypD ablation in mice also resulted in diminished disease progression for some pathologies, such as reperfusion injury of the heart and brain, axonopathy, and other neurodegenerative and demyelinating diseases (Baines et al., 2005; Schinzel et al., 2005; Giorgio et al., 2010; Halestrap and Richardson, 2015; Ahier et al., 2018; Gauba et al., 2019). This evidence concerns the gene PPIF and demyelinating disease.