Next, to determine the functional relevance of CD11b+Ly6Chi proinflammatory monocytes, we administered recombinant IFN‐α/β to WT mice at 18 h p.i., and then depleted CD11b+Ly6Chi proinflammatory monocytes by injecting anti‐mouse Ly6C antibodies at day three post N67C infection (Figure S6H, Supporting Information). This evidence concerns the gene PPIB and infection.