We found that little or low serum amounts of IFN‐α, IFN‐β, and IL‐6 were present in the WT mice 24 h after the N67C and YM infections, but the serum amounts of IFN‐α, IFN‐β, and IL‐6 were markedly increased in all the KO mice (Figure 1E–I; Figure S1C, Supporting Information), suggesting that MDA5, MAVS, cGAS, or STING deficiencies promote an early robust cytokine production in response to N67C or YM infections. The gene discussed is IFNB1; the disease is infection.