To test this possibility, we generated Mavs–/–Il6–/– DKO mice by crossing Mavs–/– mice with Il6–/‐ mice and found that the DKO mice generated strong immunity against N67C infections with lower parasitemia levels and markedly prolonged mouse survival compared to WT and Mavs–/– mice (Figure 3E,F). This evidence concerns the gene MAVS and infection.