Similarly, we found that the mRNA levels of Pdcd1 (PD‐1), Cd274 (PD‐L1), Tim3, Lag3, and Ctla4 were significantly increased in the splenocytes and lymph nodes of WT and Mavs–/– mice compared with those in Tmem173gt, Mb21d1–/–, and anti‐IL‐6R‐treated Mavs–/– mice after N67C infections (Figure 5J–L; Figure S5J, Supporting Information). This evidence concerns the gene CTLA4 and infection.