To identify potential cytokine‐production patterns in WT and KO mice in response to N67C or YM infection, we infected WT, Ifih1–/–, Mavs–/–, Mb21d1–/–, and Tmem173gt mice with either N67C or YM, then examined the serum amounts of IFN‐α, IFN‐β, and IL‐6 during the course of each infection. The gene discussed is IFNB1; the disease is infection.