To determine whether TLR‐MyD88 signaling can induce the late IL‐6 production, we showed that the production in Tlr7–/– and Tlr9–/– mice was similar to that in WT mice (Figure S4B, Supporting Information), suggesting that TLR7 and TLR9 are not the major signaling pathways involved in late IL‐6 production and anti‐malaria immunity in the N67C infection model. This evidence concerns the gene MYD88 and malaria.