The conventional method used to downregulate the expression of ABC transporters and reverse drug resistance in HCC is to introduce novel drugs, including cantharidin, glycyrrhizin and lamivudine, resveratrol and levistolide (Wakamatsu et al., 2007; Zheng et al., 2008; Kim et al., 2014; Ding et al., 2019). This evidence concerns the gene ABCG2 and hepatocellular carcinoma.