PIGF and colorectal carcinoma: Nevertheless, heterogenic mutations in genes, such as PIGF, RAS/RAF, and PI3K/AKT, induce CRC resistance to antibodies against vascular endothelial growth factor receptor (VEGFR) and epithelial growth factor receptor (EGFR) (Xie et al., 2020), indicating the urgent need to develop innovative strategies to combat CRC with MDR precisely and effectively.