However, Ze-IR700-mediated PDT greatly synergized with RGR-TRAIL in apoptosis induction and tissue damage in mice bearing HT29 tumor grafts (Figure 6(A)), suggesting that the synergy between PDT and RGR-TRAIL might be predominantly attributed to PDT-mediated sensitization of HT29 cells. The gene discussed is TNFSF10; the disease is neoplasm.