At the end of the observation, the average volumes of tumor xenografts treated with PBS or monotherapy of Ze-IR700-mediated PDT (PDT) and RGR-TRAIL were 754.1 mm3, 514.4 mm3, and 600.9 mm3, respectively, compared with the 40.9 mm3 of that of tumor xenografts treated with combination therapy (PDT + RGR-TRAIL). Here, TNFSF10 is linked to neoplasm.