SLC12A3 and cancer: As a cancer of NCC-derived melanocytes, melanoma cells reactivate the NCC transcriptional program (Capparelli et al., 2022; Kaufman et al., 2016; Rambow et al., 2018) and follow environmental cues to migrate along NCC pathways (Bailey et al., 2012), suggesting that NCCs migrate and melanoma cells metastasize using shared mechanisms.