In addition, according to data from PC tissues in the TCGA database (R = 0.25, P < 0.001; Figure 7(c)) and 48 PC tissues from our research group (R = 0.4079, P < 0.001; Figure 7(d-e)), we observed that TRA2A was co-expressed with HIF1α. The gene discussed is HIF1A; the disease is pachyonychia congenita.