Various questionnaires are used to determine alcohol dependency, such as CAGE, MAST, and AUDIT. ALT, AST, AST/ALT, physical examination, hepatic imaging, and liver biopsy are used to establish the ALD diagnosis. Alcohol abstinence, naltrexone, or acamprosate in those who achieve abstinence, and nutritional therapy are recommended in ALD, while a separate treatment algorithm is followed for alcoholic hepatitis. Liver transplant in used in cirrhosis [89]. The gene discussed is GPT; the disease is Cirrhosis.