Moreover, macrophages differentiate into M1 phenotype in damage‐associated molecular patterns, release proinflammatory cytokines, such as tumor necrosis factor α (TNF‐α), interleukin‐6 (IL‐6), and interleukin‐23 (IL‐23), aggravate the local and systemic inflammation of the pancreas and eventually cause systemic inflammatory response syndrome.4 This evidence concerns the gene TNF and systemic inflammatory response syndrome.