2019). Th1/Th2 cytokine balance has been reported to be involved in the development and treatment of hyperhidrosis. Yang (2016) pointed out that the switch from Th1 to Th2 in pregnant women could lead to the deterioration of sweat glands function related diseases such as hidradenitis and hyperhidrosis. Wang et al. (2020) found that TNF-α can inhibit the differentiation of mesenchymal stromal cells into sweat gland cells, which may have a great impact on the sweating state. The gene discussed is TNF; the disease is Hyperhidrosis.