SREBF2 and metabolic dysfunction-associated steatotic liver disease: SREBPs can activate the transcription of genes involved in the synthesis of cholesterol, fatty acids, and phospholipids.35,36 The association between SREBF2 and NASH is well established: SREBF2 mRNA levels are three times higher in NASH patients than in healthy controls, and acyl-CoA cholesterol acyltransferase was 1.5-fold increased.37 Thus, chronic carbohydrate consumption may stimulate SREBP expression and the subsequent upregulation of hepatic DNL, leading to excessive lipid accumulation and the onset of NAFLD.