The expression of USF1, NR1H3, and MLXIPL was lower (P = .022, P = .009, and P = .045, respectively) and the expression of SCD and mTOR was higher with increasing NAFLD activity in the LC group (SCD, P = .009 [N2 vs. N0]; mTOR, P = .035 [N0 vs. N1]; and P = .022 [N0 vs. N2]). This evidence concerns the gene USF1 and metabolic dysfunction-associated steatotic liver disease.