Although no clear correlation was found between PI4K2A and immunotherapy‐related features such as neoantigens, MSI, TMB, and tumor microenvironment, immune cell correlation analyses identified that PI4K2A expression levels were corresponded to immune cell infiltration such as CD4+ infiltration, macrophage infiltration, neutrophil infiltration, and dendritic cell infiltration were closely correlated. Here, CD4 is linked to neoplasm.