VEGFA and age-related macular degeneration: While intravitreal anti-VEGF has a well-established role in the treatment of proliferative DR, agents such as aflibercept have also shown promise in the reversal of nonproliferative DR.18 A study by Soiberman et al. in Israel13 demonstrated how intravitreal anti-VEGF resulted in lower serum IMA levels in a sample of patients with retinal vascular disease due to age-related macular degeneration or diabetic macular edema.