WFDC2 and ovarian cancer: Compared with the control group, the BL and OC groups experienced a marked increase in serum miR-21, HE4, and CA125 expression (p< 0.05, respectively), with the serum levels of miR-21, HE4, and CA125 in the OC group significantly higher than in the BL group (p< 0.05, respectively).In the ovarian cancer patients, serum miR-21, HE4, and CA125 expression levels were independent of pathological patterns (p> 0.05) and associated with the clinical staging, degree of transformation and lymphatic metastasis of ovarian cancer (all p< 0.05).