Particularly, the serum levels of miR-21, HE4, and CA125 were substantially higher in patients with stage III-IV ovarian cancer showing a low degree of differentiation and lymphatic metastasis.Compared with the preoperative levels, serum miR-21, HE4, and CA125 expression in patients with ovarian cancer were significantly reduced after laparoscopic ovarian tumorectomy (p< 0.05, respectively). The gene discussed is WFDC2; the disease is ovarian cancer.