To be specific, ovarian cancer patients with serum miR-21 >1.536, serum HE4 >157.004 pmol/L and serum CA125 >175.243 kU/L were at higher risk for poor prognosis, under which circumstance early intervention should be made to prevent recurrence and metastasis of ovarian cancer. The gene discussed is WFDC2; the disease is ovarian cancer.