To be specific, ovarian cancer patients with serum miR-21 >1.536, serum HE4 >157.004 pmol/L and serum CA125 >175.243 kU/L were at higher risk for poor prognosis, under which circumstance early intervention should be made to prevent recurrence and metastasis of ovarian cancer. This evidence concerns the gene WFDC2 and ovarian carcinoma.