BNP levels rises soon after cardiac ischemia due to stress, according to several reports.19 The results not only demonstrate the connection between BNP and pathogenesis of ACS, but also suggest that BNP may have diagnostic and prognostic value in patients with MI who present to the CCU as evident from the work of Arafath et al.20,21 Similar findings are suggestive from the work of Noureen et al.22 This evidence concerns the gene NPPB and myocardial ischemia.