During early pregnancy, the increase in maternal fat deposits is facilitated by insulin, followed by increased adipose tissue breakdown and subsequent hypertriglyceridemia, mainly as a result of insulin resistance (IR) and estrogen effects.14 It was found in our study that the levels of TG, TC, LDL-C, FBG, FINS, C peptide and HbA1c in patients with GDM were significantly higher than those in healthy population. The gene discussed is INS; the disease is Insulin resistance.