IL-18 is a typical Th1-type cell, which can stimulate the Th1-mediated immune response and has close bearing on the severity of MP.17 In this study, the observation group had higher serum levels of CD4+, CD4+/CD8+, 25-(OH)D, as well as lower CD8+, IL-6, LDH than control groups A and B after treatment (p<0.05), suggesting that Reduning combined with gamma globulin in the treatment of severe MP can significantly enhance the body’s immune function and inhibit inflammation. The gene discussed is IL18; the disease is hyperplastic polyp.