IL-18 is a typical Th1-type cell, which can stimulate the Th1-mediated immune response and has close bearing on the severity of MP.17 In this study, the observation group had higher serum levels of CD4+, CD4+/CD8+, 25-(OH)D, as well as lower CD8+, IL-6, LDH than control groups A and B after treatment (p<0.05), suggesting that Reduning combined with gamma globulin in the treatment of severe MP can significantly enhance the body’s immune function and inhibit inflammation. This evidence concerns the gene CD8A and hyperplastic polyp.