The Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) study demonstrated that 24% of new-onset DKD patients with type 1 diabetes mellitus (T1DM) progressed to eGFR < 60 ml/min per 1.73 m2 but had albumin excretion rates < 30 mg/24 h at all prior evaluations (4). The gene discussed is ALB; the disease is diabetes mellitus.