Furthermore, cancer-causing mutations in any of Ret Proto-oncogene (RET), neurotrophic tyrosine receptor kinase (NTRK), RAS, B-Raf proto-oncogene (BRAF), or telomerase reverse transcriptase (TERT) gene are linked to loss of thyroid-differentiating genes, including NIS (15–17). The gene discussed is RET; the disease is cancer.