In DKD models, isoliquiritigenin (ISLQ), baicalin, astragaloside IV, ligustilide, nicotinamide mononucleotide (NMN), and Tangshen formula have been shown to increase or activate SIRT1 through the SIRT1/NF-κB signaling pathway to improve inflammation, decrease apoptosis, and enhance autophagy (80–86). The gene discussed is SIRT1; the disease is diabetic kidney disease.