Another study of gene polymorphisms suggested that, among 1016 patients with T2DM (388 without DKD and 628 with DKD), the transcriptional coactivator p300 rs20551 polymorphism is associated with the development of DKD, and the SIRT1 polymorphism is related to albumin-creatinine ratio progression (36). This evidence concerns the gene SIRT1 and type 2 diabetes mellitus.