SIRT1 and type 2 diabetes mellitus: Single nucleotide polymorphisms were analyzed by including 1066 patients with type 2 diabetes (T2DM) (413 without DKD and 653 with DKD), and the results indicated that the SIRT1 gene variant rs10823108 and the FoxO1 gene variant rs17446614 may be associated with DKD in patients with T2DM (35).