Tables 1, 2 show that both natural (Table 1: S17 and Table 2: S13, S14) and non-natural (Table 1: S1, S7 and Table 2: S7–S10) substances restored molecular mechanisms involved in neurogenesis alterations in DS (e.g., p21 levels or GSK3ß phosphorylation), indicating, significantly, that it is possible to bypass pharmacologically triplicated genes and that this action may be achieved with a variety of agents. Here, CDKN1A is linked to Dravet syndrome.