Among the STATs, STAT3 specifies glial cell fate through transcriptional activation of astrocytic genes, such as GFAP and S100beta. IFNAR1, IFNAR2, IFNGR2, and IL10RB are upregulated in DS fibroblasts, rendering them more sensitive to interferon and inducing greater activation of the IFN pathways (Sullivan et al., 2016). The gene discussed is IFNAR2; the disease is Dravet syndrome.