RCAN1 and Dravet syndrome: RCAN1 is overexpressed (RNA) in the fetal DS brain at GW20 (Guimera et al., 1999) and GW22 (Fuentes et al., 2000), in lymphoblastoid cell lines from children with DS (Granese et al., 2013), and in cultured amniocytes from fetuses with DS (Altug-Teber et al., 2007).