DYRK1A is the more intensively studied gene in DS (Atas-Ozcan et al., 2021) because it plays an important role in neurogenesis, is highly expressed during embryonic neurogenesis, and Dyrk1a transgenic mice exhibit brain alterations that are reminiscent of DS (Hammerle et al., 2003). Here, DYRK1A is linked to Dravet syndrome.