Increased levels of DYRK1A, p53, and p21CIP1 have been found in the frontal cortex of fetuses and adults with DS (Park et al., 2010), and increased levels of p21CIP1 have been found in the brains of fetuses with DS (Engidawork et al., 2001). The gene discussed is DYRK1A; the disease is Dravet syndrome.