Very recent evidence shows that DS-hiPSC-derived cerebral organoids present defects that are very similar to those of the fetal DS brain, such as volume reduction, reduced number of proliferating cells in VZ-like regions, reduced number of neuronal progenitors (SOX2+ cells), and no change in the expression of apoptotic markers (Tang et al., 2021). The gene discussed is SOX2; the disease is Dravet syndrome.