In the fetal DS brain, APP was found to be increased in the temporal cortex (protein) at GW17-21 (Guidi et al., 2017), whole cortex (protein) at GW14 and GW21 (Lu et al., 2011), whole cortex (RNA) at GW15-37 (El Hajj et al., 2016), and whole brain (protein and RNA) at GW19 (Tanzi et al., 1987, 1988). Here, APP is linked to Dravet syndrome.