ARID4B and Insulin resistance: The elevated BCAA levels in obese and/or diabetic individuals could be attributed to defective BCAA catabolism, as corroborate by the findings that BCAA catabolic enzymes are decreased in the obese ob/ob mice and fa/fa rat as well as obese humans (28), and that increasing BCAA catabolism by BT2 attenuates insulin resistance in ob/ob mice (13).