Other evidence supporting this model includes the reports of glucocorticoid resistance, inflammation and depressive-like behaviours in the aforementioned repeated social defeat animal models of depression [45] and a study showing that administration of dexamethasone (a synthetic glucocorticoid and GR agonist) leads to reduced GR target gene expression in patients with depressive disorders and mouse models [2]. The gene discussed is NR3C1; the disease is major depressive disorder.