For example, miR-148a regulates antigen presentation of TLR-triggered dendritic cells (36), osteoclastogenesis of CD14+ peripheral blood mononuclear cells (37), LDL receptor activity in human hepatic cells (38), and functions as a tumor suppressor miRNA in various types of cancers including gastric, colorectal, hepatocellular and pancreatic cancers (39–42). The gene discussed is LDLR; the disease is familial pancreatic carcinoma.