Among them, IL22 shows the strongest association, which may indicate that epithelial barrier functions modulated by IL-22 may be important in COVID-19 (48).” In addition, the ABO locus led by the variant rs687621 also showed statistically significant impact on several immune-mediated traits, including cell counts of lymphocytes (Coloc analysis H4: 0.98), monocytes (Coloc analysis H4: 1), neutrophils (Coloc analysis H4: 0.8), and whole blood cells (Coloc analysis H4: 1) (Figure 3D). Here, ABO is linked to COVID-19.