The inhibitory effect of the small molecule inhibitor, BAY-299, on BRD1 partially leads to increased NK cell maturation, activation, and tumor cell killing via alteration of the chromatin pathway of key immune transcription factors (e.g., GATA3, TBX21, and TBXT), induces similar state transitions in immune cells in vitro and in vivo and demonstrates the in vivo efficacy of bispecific antibodies (73). Here, BRD1 is linked to neoplasm.