For example, tumor-associated neutrophils (TANs) can impair the cytotoxicity and infiltration capacity of NK cells, and downregulation of CCR1 leads to diminished infiltration capacity of NK cells and reduced responsiveness of the NK-activating receptors NKp46 and NKG2D (34); CD56dimPD-1+ NK cells expressed in patients with Hodgkin lymphoma are efficiently inhibited by PD-L1-expressing myeloid cells (35). The gene discussed is CD274; the disease is neoplasm.