Considering NK cell-mediated cytotoxicity does not require MHC class I and the unique effects of anti-PD-1/PD-L1 mAb therapy on NK cell function described above, adoptive transfer of autologous or allogeneic NK cells together with anti-PD-1/PD-L1 antibodies may potentially enhance the outcomes of patients receiving cancer immunotherapy. This evidence concerns the gene CD274 and cancer.