In humanized (Hu) NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG) mice xenografted with dedifferentiated liposarcoma (DDLPS), abundance of hCD8+ T subsets, such as hCD8+ IFN-γ+, hCD8+PD-1+, and hCD8+Ki-67+ cells, and hNK subsets, such as hCD56+IFN-γ+, hCD56+PD-1+, and hCD56+Ki-67+ cells, is functionally associated with anti-PD-1 effects (58). The gene discussed is IFNG; the disease is liposarcoma.