NK cells in tumor-infiltrating and draining lymph nodes were reported to show upregulation of the inhibitory molecule PD-L1, which transmits an inhibitory signal by interacting with PD-1 expressed on DCs to limit the activation of these cells; this in turn leads to a decrease in the priming ability and memory response of tumor-specific CD8+ T cells (61). This evidence concerns the gene CD274 and neoplasm.